The B2B Stack

The B2B Stack

Agentic Is Rewiring Advertising But In B2B It's Theatre. Substrate Is the Fix.

Agentic layers are delivering real value already; 87% reductions in campaign setup time, 70% faster troubleshooting, and 40% more impressions at 30% lower effective CPMs against comparable benchmarks

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Mike Harty
May 18, 2026
∙ Paid

AdExchanger’s inaugural Programmatic AI event opens in Las Vegas today. Three days, headlined “Mastering the Shift to Intelligent Media,” pitched as the industry’s first dedicated forum for the practical realities of agent-led advertising.

Every DSP, SSP, and analytics vendor that’s shipped an “agent” or a “kit” or an “OS” in the last six months will be on stage, and a credible portion of the buy side will be in the room.

For B2B this is theatre. Substrate is the fix, and in this context, substrate means the underlying layer of data and context that an agent reasons over to make decisions. It's the foundation underneath the agent, not the agent itself. Fixing that is the only way to make agentic work for B2B, as we’ll explore below

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I missed the memo in time to get out there. Genuinely sore about it. The agentic shift in programmatic is the most interesting structural change since real-time bidding, and watching it unfold from just outside of Lon…

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